Muriel DUFLOS

Professor Muriel Duflos is a faculty member at the University of Nantes, affiliated with the Faculty of Pharmacy and the Department of Drug Development and Evaluation. Her research focuses on anti-inflammatory, antidiabetic, and anticancer drug development, with a strong emphasis on organic synthesis and medicinal chemistry. She holds a PhD in Chemistry from the University of Rennes (1991) and became a full Professor in 2003 after serving as a Lecturer since 1994. Her work involves designing and synthesizing novel compounds, evaluating their biological activity, and advancing drug candidates for therapeutic applications.

Education:

• Qualification to direct research (1995)
• Doctorate in Chemistry, University of Rennes (1991)
• Chemical Engineer, ESCOM (1988)
• DEA in Spectroscopy (1988)

Research Interests: Professor Duflos specializes in the synthesis of heterocyclic compounds, particularly naphthyridines and pyrimidines, with applications in anticancer, antifungal, and kinase inhibitor therapies. Her lab focuses on optimizing synthetic routes using advanced methods like cross-coupling reactions and microwave-assisted chemistry. Key themes include structure-activity relationships (SAR), bioactivity screening, and drug design targeting Hsp90, CLK1/DYRK1A kinases, and other therapeutic pathways.

Articles Overview: Her recent publications highlight efforts to synthesize novel compounds and evaluate their efficacy in inhibiting cancer cell growth, fungal pathogens, and kinase enzymes. Techniques such as X-ray crystallography and palladium-catalyzed reactions are frequently employed to characterize and optimize molecular structures. Collaborative efforts in marine-derived natural products further expand her research into discovering bioactive compounds from unconventional sources.

Awards: No scientific awards explicitly mentioned in the text.

Grants & Advising: While specific grants are not detailed, her research aligns with funded programs in drug development and organic synthesis. No student advisees are listed in the provided materials.

Labs & Teams: Active in the Department of Drug Development and Evaluation at the University of Nantes, contributing to interdisciplinary projects in medicinal chemistry and pharmacology.