معرفی
Summary
Minghao Chen is an Associate Research Scientist in the Genetics department at Yale School of Medicine. He holds a MD and PhD from Southern Medical University (2016). His research focuses on vascular biology, mechanotransduction mechanisms in endothelial cells, and the pathophysiology of aortic aneurysms and diabetes-related vascular complications. Key projects include studying integrin signaling pathways (α5β1 integrin) in Marfan syndrome and diabetic vasculopathy, as well as fluid shear stress effects on arterial remodeling via Latrophilin-2 and Smad2/3 signaling.
Education: PhD and MD from Southern Medical University (2016). Active collaborations include teams led by Martin Schwartz (Schwartz Lab), Anthony Koleske, and George Tellides. His work spans basic science (mechanobiology) to translational research in cardiovascular diseases.
Research Interests:
- Mechanotransduction in vascular systems
- Pathogenesis of thoracic aortic aneurysms
- Diabetes-induced vascular dysfunction
- Integrin-mediated cell signaling
- Fluid dynamics in vascular remodeling
Publications emphasize mechanistic studies in mice models and human tissue analysis, with recent work appearing in EMBO Journal, Arteriosclerosis Thrombosis & Vascular Biology, and Diabetes.
