معرفی
Dr. Ying H Shen, M.D., Ph.D., is a Professor of Surgery at Baylor College of Medicine and serves as the Director of the Aortic Disease Research Laboratory. She is affiliated with the Division of Cardiothoracic Surgery and has joint affiliations with the Texas Heart Institute. Her work bridges clinical surgery and translational vascular biology, with a focus on aortic diseases and diabetic vascular complications.
Education:
- Ph.D. in Biomedical Sciences — University of New South Wales, Sydney, NSW, Australia
- M.D. — Beijing Medical College, Beijing, China
Research Interests:
Dr. Shen's research is centered on understanding the molecular mechanisms underlying aortic aneurysms and dissections. Her laboratory investigates signaling pathways that regulate aortic destruction, healing, and remodeling. She has developed innovative mouse models to study these processes and applies advanced techniques to assess aortic structure and function. A key translational goal is the development of pharmacological strategies to prevent progressive aortic disease. She also explores diabetic vascular diseases and the role of inflammation and metabolic dysfunction in vascular biology.
Recent Research Trends:
Her recent publications (2017–2023) emphasize epigenetic regulation, single-cell transcriptomics, inflammasome signaling, and the role of innate immune pathways such as STING and NLRP3 in aortic degeneration. There is a consistent focus on identifying therapeutic targets for aortic aneurysm and dissection, including the adverse effects of drugs like ciprofloxacin in genetically predisposed individuals.
Scientific Awards:
- Dr. Mark L. Entman Teaching Award for Excellence in Cardiovascular Education (2023)
Grants & Funding:
Dr. Shen has received major funding from the NHLBI, including an R01 grant awarded jointly with Dr. LeMaire, to study gender differences in aortic disease. Her lab is supported by multiple federal and institutional grants aimed at dissecting the molecular basis of vascular pathology and developing targeted therapies.
Laboratory & Team:
She directs the Aortic Disease Research Laboratory at Baylor College of Medicine, in collaboration with the Texas Heart Institute. Her team includes postdoctoral fellows, graduate students, and research staff working on translational vascular biology projects.
