معرفی
Mickaël Ménager is the team leader (chef d'équipe) of the SCInflaNet: Single-Cell Inflammatory Responses and multi-OMICs Networks research group at the Imagine Institute. His work focuses on understanding inflammatory diseases and HIV-1 pathogenesis through cutting-edge single-cell transcriptomics, network inference, and computational biology. His research integrates genomic, proteomic, and cellular approaches to dissect mechanisms of autoinflammatory diseases like Aicardi-Goutières Syndrome (AGS) and HIV-DC interactions.
Research Interests: Ménager’s lab investigates: 1) regulatory networks driving type I IFN dysregulation in autoinflammatory diseases, and 2) HIV-1 sensing, transfer to T-cells, and host immune responses. Key projects include:
- Single-cell network analysis to identify molecular drivers of IFN overproduction in AGS
- Actin dynamics and HIV transfer mechanisms in dendritic cells (DCs)
- Computational modeling of transcriptional networks using tools like the Inferelator
Collaborations & Tools: Collaborates with Richard Bonneau’s lab (Simons Foundation) to develop dynamic gene regulatory networks. Uses bulk RNA-seq, ATAC-seq, and shRNA screens to study DC maturation, HIV endocytosis, and actin nucleation pathways. His team pioneered insights into TSPAN7’s role in HIV transfer and RARA’s regulation of DC activation.
Labs & Teams: Leads SCInflaNet within the Imagine Institute, a premier center for genetic disease research. Active in multi-omic platforms and translational medicine, with a focus on developing therapies to replace immunosuppressive treatments in autoinflammatory disorders.
