معرفی
Michelle Chang is the A. Barton Hepburn Professor of Chemistry at Princeton University, leading a research group focused on biocatalysis, synthetic biology, and enzyme engineering. Her work bridges enzymology and metabolic engineering to address challenges in health and sustainability.
Education: Ph.D., Massachusetts Institute of Technology (2004); Postdoctoral training at UC Berkeley (2004–2007). Current affiliations include the Princeton Chemistry Department and collaborations with institutions like the Lawrence Berkeley National Lab.
Research interests include designing biosynthetic pathways for small molecules, engineering enzymes for C-H activation, and developing microbial systems for biofuel and bioplastic production. Key projects involve fluorinated natural products, non-photosynthetic CO₂ fixation, and biocatalytic fluorine incorporation.
Publications emphasize enzyme mechanisms (e.g., radical halogenases), metabolic engineering (e.g., archaeal bioplastic production), and chemoenzymatic synthesis. Recent work highlights advancements in enzyme specificity control and sustainable chemical production.
Recipient of over 20 awards, including the Arthur Cope Scholar Award (2015), Royal Society Centenary Prize (2022), and ACS Fluorine Chemistry Award (2024). Advises graduate students and postdocs in experimental and computational biology.
Labs and teams focus on interdisciplinary approaches, integrating crystallography, NMR, and metabolic modeling. Current group members include Elijah Kissman, Andrew Whitten, and Veronica Stafford.
