معرفی
Dr. Michael Tomlinson is an Associate Professor (Reader) in Membrane Protein Biology, specializing in the regulation of membrane proteins by tetraspanins. His work focuses on the 'molecular scissor' ADAM10 and its role in diseases like cancer, Alzheimer's, and cardiovascular conditions. He holds a PhD from the University of Oxford (1995) and a BSc (Hons) in Applied Biology from the University of Bath (1991).
Research Interests: Investigating how tetraspanins modulate ADAM10 activity and localization, with a focus on therapeutic targeting. Key projects include the 'six scissor' hypothesis and the impact of TspanC8 proteins on ADAM10 substrate specificity.
Grants & Projects:
- Principal Investigator for 'MRC IAA: Developing a novel workflow for therapeutic antibody generation' (2023–2024).
- Co-Investigator in 'A mass spectrometer for structural biology' (2024–2025) and 'Coronavirus binding assay' (2021).
Labs/Teams: Collaborates widely on structural biology, platelet receptor biology, and therapeutic development, leveraging advanced techniques like CRISPR/Cas9 and mass spectrometry.
