Stephen Charles Blacklow

Stephen Charles Blacklow is the Gustavus Adolphus Pfeiffer Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, specializing in molecular mechanisms of signal transduction with a focus on the Notch signaling pathway. His research explores how Notch proteins mediate cell-cell communication, particularly in developmental processes and cancer pathogenesis. Key interests include ADAM-family protease activation, transcriptional regulation by Notch, and feedback mechanisms.

Education details are not explicitly provided in the texts, but his roles indicate advanced training in biological chemistry and molecular pharmacology. Research awards include election to the American Academy of Arts & Sciences in 2025.

Notable lab members include Ruili, Drew Dates, Lena Tveriakhina, and Alex Martin, with a focus on collaborative projects such as Notch ligand design, phosphatase inhibition, and B cell co-receptor dynamics. His lab employs structural biology, proteomics, and systems biology approaches to dissect signaling pathways.

Recent work highlights spatiotemporal mapping of Notch signaling from membrane to nucleus, ADAM10 substrate specificity, and tetraspanin protein interactions. Ongoing studies investigate therapeutic modulation of Notch pathways in cancer and developmental disorders.