معرفی
Stephen C. Blacklow is a Professor at Harvard Medical School, serving as Gustavus Adolphus Pfeiffer Professor Chair in the Department of Biological Chemistry and Molecular Pharmacology. He is also a member of the Department of Cancer Biology at the Dana-Farber Cancer Institute.
Research Interests: The Blacklow laboratory investigates biochemical and molecular mechanisms of signal transduction, with a primary focus on the Notch signaling pathway in health and disease. Their work encompasses structure-function studies of Notch receptors, regulated intramembrane proteolysis, and nuclear transcriptional activation complexes, alongside exploring Notch modifiers in oncogenic contexts.
Publication Trends: Recent articles highlight structural biology approaches to Notch signaling, tetraspanin interactions, and proteolytic activation mechanisms, with keywords spanning
- Notch pathway regulation
- Signal transduction biophysics
- Membrane-proximal proteolysis
- Transcriptional activation dynamics
- B cell co-receptor networks
Key Contributions: The lab has made seminal discoveries about Notch activation through mechanical force requirements and juxtamembrane mutation-driven oncogenesis in T-ALL, while also advancing understanding of Mind Bomb E3 ligase substrate recognition.
Laboratory Affiliation: The Blacklow Laboratory operates within Harvard Medical School's LHRRB Building, with a dedicated focus on structural and functional analysis of signaling proteins.
