Michael T Green

Michael T. Green is a Professor of Chemistry at the University of California, Irvine (UCI), specializing in chemical biology and enzymology. His research focuses on understanding the mechanisms of metalloprotein-catalyzed C-H bond activation, particularly in cytochrome P450 enzymes. His work combines theoretical and experimental approaches to elucidate the roles of thiolate-ligated heme in selective oxidation reactions and protein stability.

Key Research Contributions:

• Characterization of P450 Compound I and its role in substrate oxidation
• Discovery of ferryl pKa's role in suppressing non-productive oxidations
• Development of neutron diffraction and Mössbauer spectroscopy techniques for enzyme intermediates

Lab Activities: The Green group investigates heme protein chemistry, with a focus on P450's synthetic potential and biological selectivity. Their work has been highlighted in Chemistry World, Nature Chemistry, and Angewandte Chemie.

Future Work: Ongoing projects aim to translate P450-inspired mechanisms into synthetic catalysts and improve understanding of C-H bond activation pathways.