معرفی
Dr. Michael Lee is an Assistant Professor of Medicine in the School of Medicine at the University of California, San Francisco (UCSF), specializing in pulmonary vascular diseases with a particular focus on pulmonary hypertension related to schistosomiasis and connective tissue disorders. His research integrates metabolomics, immunology, and vascular biology to uncover disease mechanisms and identify novel therapeutic targets.
Dr. Lee completed his medical training at New York University, earning his MD in 2013, followed by Internal Medicine Residency (2016) and service as Chief Resident (2017). He further specialized through a Pulmonary Sciences and Critical Care Medicine Fellowship at the University of Colorado, completed in 2020.
His research program centers on the metabolic underpinnings of pulmonary hypertension, with significant contributions to understanding the roles of macrophages, T cells, and metabolic dysregulation in disease pathogenesis. Dr. Lee's work has established important connections between parasitic infections, autoimmune disorders, and pulmonary vascular pathology, with increasing emphasis on metabolomics approaches to study transpulmonary gradients and cellular metabolism.
Analysis of Dr. Lee's publication record reveals a sophisticated research trajectory focused on the intersection of pulmonary hypertension with infectious diseases (particularly schistosomiasis), connective tissue disorders, and metabolic pathways. His recent work demonstrates methodological sophistication through metabolomics integration and has expanded into exercise physiology applications and novel therapeutic approaches for pulmonary hypertension.
- Fulbright U.S. Scholar (2022-2023)
- NIH K08 Career Development Award recipient (2023-2028)
- U.S. Department of Defense grant recipient (2022-2025)
- CHEST Foundation Research Grant recipient (2021-2022)
Dr. Lee serves as Principal Investigator on multiple significant research projects totaling millions in funding. His NIH K08 award investigates hypoxia inducible factor-1-dependent glycolysis in lung interstitial macrophages related to schistosomiasis-induced pulmonary hypertension. He also leads a Fulbright U.S. Scholar project on transpulmonary metabolomics in systemic sclerosis-associated pulmonary arterial hypertension and a Department of Defense project examining dysregulated pulmonary vascular metabolism. His research has established important connections between parasitic infections, autoimmune disorders, and pulmonary vascular disease.
Dr. Lee collaborates extensively with the Graham laboratory at UCSF and maintains international research partnerships in Ethiopia and Zambia studying schistosomiasis-associated pulmonary hypertension. His work involves multidisciplinary teams including immunologists, metabolomics specialists, and clinicians specializing in pulmonary vascular diseases. He is actively involved in the Division of Pulmonary and Critical Care Medicine at UCSF, contributing to both clinical care and research initiatives focused on rare pulmonary vascular disorders.
