معرفی
Dr. Pui Lee is an Attending Physician in Rheumatology at Boston Children’s Hospital and Assistant Professor of Pediatrics at Harvard Medical School. His research focuses on autoinflammatory diseases, myeloid cell biology, and immunometabolism.
Education:
- MD-PhD, University of Florida College of Medicine (2010)
- Internship, Boston Children's Hospital (2011)
- Residency, Boston Children's Hospital (2013)
- Fellowship, Boston Children's Hospital (2016)
Dr. Lee's primary research investigates how immunometabolism regulates monocyte development and inflammation, with emphasis on macrophage activation syndrome (MAS) and deficiency of adenosine deaminase 2 (DADA2). His laboratory explores metabolic reprogramming in myeloid cells and immune activation mechanisms in cytokine storm syndromes. Current projects include studying monocyte differentiation pathways and vascular inflammation in DADA2.
His 15 most recent publications (2023-2025) demonstrate expertise in pediatric rheumatology, with recurring themes in cytokine storm pathogenesis, monocyte/macrophage biology, and genetic autoinflammatory disorders. Key areas include MAS biomarkers, DADA2 mechanisms, and immunometabolic drivers of inflammation.
Scientific Contributions:
- Developed screening algorithms for lung disease in systemic JIA
- Characterized IL-17 elevation as Kawasaki disease biomarker
- Defined SOCS1 haploinsufficiency as autoimmunity driver
- Elucidated DADA2 vascular pathology mechanisms
Dr. Lee actively contributes to clinical guidelines including international consensus statements on DADA2 management. His research bridges basic immunometabolism with translational applications for pediatric inflammatory disorders, with focus on identifying novel treatment targets for refractory conditions.
