معرفی
Dr. Metodi Metodiev is a Senior Lecturer at the School of Life Sciences, Department of Biological Sciences, University of Essex. He has been in this role since October 2011, following previous positions as Lecturer (2004–2011) at the same institution and as Research Assistant Professor (1999–2004) at the University of Illinois at Chicago's Laboratory for Molecular Biology. His research focuses on translational and basic cancer biology, combining computational proteogenomics with experimental techniques to identify diagnostic biomarkers and drug targets. He also uses CRISPR/Cas9 to study molecular mechanisms of signal transduction in cancer, particularly the tumor suppressor SCRIB, integrating these methods into student research projects.
Metodi holds a PhD in Biological Sciences from the Bulgarian Academy of Sciences (1994), an MSc in Biology from Sofia University St Kliment Ohridsky (1989), and a Post-graduate certificate in C programming for Bioinformatics from the University of Manchester (2004). His academic support hours are on Fridays from 14:00–16:00.
His research interests span cancer biology, proteogenomics, signal transduction pathways, CRISPR/Cas9 gene editing, biomarker discovery, and computational bioinformatics. He explores the molecular basis of tumor progression, particularly in breast and cervical cancers, and investigates microbial proteome dynamics in response to environmental stressors. His work bridges computational models with lab experiments, emphasizing personalized therapy and microbial adaptation mechanisms.
His publications reflect a focus on cancer biomarkers, proteomic tools, and microbial physiology. Recent studies highlight advancements in breast cancer prognosis using national registries, cervical cancer progression via ROMO1, and CRISPR-based exploration of tumor suppressors. Earlier work includes proteomic profiling of marine microbes under environmental changes and yeast signaling pathways.
Metodi has supervised multiple PhD students, including Dr. Nikos Parisis, Dr. Fahri Hejazi, Dr. Esther Adewuyi, and Dr. Samson Adoki. Current advisees are Mrs. Makarim Al-Zubaidi and Ms. Nosheen Faiz (co-supervised). No specific grants are detailed in the provided texts, but his research is supported through institutional and collaborative efforts.
His research group operates within the University of Essex's Life Sciences facilities, continuing work initiated at the University of Illinois at Chicago's Laboratory for Molecular Biology. They integrate computational tools with experimental biology to address translational challenges in cancer therapy and microbial adaptation.
