Matthias Zilbauer

Matthias Zilbauer is a Clinical Professor of Paediatric Gastroenterology at the University of Cambridge, affiliated with the Department of Paediatric Gastroenterology, Hepatology and Nutrition and the Cambridge Stem Cell Institute. He holds an MD from the University of Mainz and a PhD from University College London (UCL), focusing on mucosal immunology. His research group studies intestinal epithelial stem cell biology, epigenetic mechanisms in health and diseases like Inflammatory Bowel Diseases (IBD) and Necrotising Enterocolitis (NEC). Key projects include developing clinical biomarkers for IBD, testing novel therapies using organoid models, and creating 2D/3D co-culture systems integrating immune cells and microbiota.

His team maintains a large biobank of over 1000 human intestinal organoid lines. Key collaborators include the Medical Research Council (MRC), Helmsley Charitable Trust, and Action Medical Research. Zilbauer leads a dynamic group with active PhD students and postdocs, focusing on translational research to improve pediatric gastrointestinal care. His work bridges basic science and clinical applications, emphasizing epigenetic regulation, organoid technology, and precision medicine.