معرفی
Martin Enge is a Senior Researcher and Associate Professor in the Department of Oncology-Pathology at Karolinska Institutet. He holds a Medicine Doctoral degree (2009) from Karolinska Institutet and has been recognized for developing innovative single-cell multiomics methodologies to study cancer biology.
- Employment: Senior Researcher (2022-), Associate Professor (2023)
- Location: Bioclinicum v6, Stockholm
His research focuses on clonal evolution, gene regulation, and cell interaction in cancer, particularly in pediatric acute lymphoblastic leukemia (ALL). He investigates how both genetic and epigenetic changes drive tumor progression and response to treatment, using advanced single-cell techniques to distinguish cancer stem cells from stochastic models of tumor growth.
His 15 most recent publications span topics including MYC super-enhancer regulation, single-cell transcriptomics in psoriasis, pre-malignant subclones in neuroblastoma, and chromatin interactome in colorectal cancer. These works integrate genomic, transcriptomic, and computational approaches to decode complex disease mechanisms.
Scientific Awards:
- Swedish Childhood Cancer Foundation grant (2021)
He leads the research group Cancer stem cells and clonal structure in acute lymphoblastic leukemia at Karolinska Institutet, which has developed novel methods for analyzing functional and genetic errors in individual cells across leukemias and other cancers. His lab is actively involved in understanding pre-leukemic states, relapse mechanisms, and stromal interactions in tumor microenvironments.
