معرفی
Olle Sangfelt is a Principal Researcher and Docent at the Department of Cell and Molecular Biology, Karolinska Institutet. His research focuses on the role of SCF ubiquitin ligases, cell cycle regulation, and transcriptional control in cancer development and progression. He is particularly interested in mechanisms of drug resistance and tumor recurrence.
- Education: PhD (1998) in Oncology-Pathology, Karolinska Institutet; Docent (2011).
Research areas: His work bridges molecular biology with translational cancer research, emphasizing ubiquitin signaling, replication stress response, and therapeutic vulnerability identification. Collaborations span institutions in Sweden, Italy, Finland, and the USA.
Article trends: Recent publications highlight
- SCF ligase subunits (FBXL12, FBXO44)
- SOX9-positive latent cells in medulloblastoma recurrence
- Ubiquitin-dependent DNA repair mechanisms
- Combination therapies for leukemia and neuroblastoma
- Single-cell analysis of tumor heterogeneity
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