Mark Von Zastrow

Mark Von Zastrow is a Professor of Psychiatry at the University of California, San Francisco (UCSF) School of Medicine. He is affiliated with the UCSF Weill Institute for Neurosciences, focusing on receptor biology and cellular mechanisms in psychiatric contexts.

• Research Focus: Membrane trafficking of opioid and GPCRs, pain/analgesia mechanisms, drug addiction, and endocytic pathway signaling.
• NIH Grants: Multiple long-term grants (1982-2021) including R01DA010711 for membrane trafficking studies and P01DA010154 on receptor internalization in addiction.

His work bridges pharmacology, cell biology, and neuroscience, with recent studies exploring CRISPR screening for GPCR regulators and endosomal signaling pathways. Publications span top journals like Neuron and Molecular Pharmacology, emphasizing translational implications for substance-related disorders.

• Network Collaborations: Collaborations with UCSF colleagues like Kevan Shokat and Martin Kampmann.
• Technological Contributions: Pioneering methods for studying receptor trafficking and signal transduction.