معرفی
Maria Hatzoglou is a Professor in the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine, with membership in the Molecular Oncology Program of the Case Comprehensive Cancer Center. Her research focuses on cellular stress responses in disease contexts, particularly cancer progression and metabolic disorders.
- Research Themes:
- Endoplasmic Reticulum (ER) stress mechanisms
- Translational control in chronic stress
- Metabolic reprogramming via redox-sensitive cysteine residues
- Cancer cell adaptation in breast cancer and glioblastoma stem cells
- Key Publications (2025–2013):
- Revealed novel translational plasticity in mammalian stress responses (Nature 2025)
- Discovered mTOR-dependent GCN2 phosphorylation for stress adaptation (JBC 2024)
- Linked ER stress to protein synthesis-driven cell death (Nature Cell Biology 2013)
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