معرفی
Marc Therrien is a Full Professor at the Department of Pathology and Cellular Biology, Faculty of Medicine, University of Montreal. He leads the Unité de recherche en signalisation intracellulaire at the IRIC (Institut de recherche en immunologie et en cancérologie). His research focuses on the RAS-MAPK signaling pathway, particularly its role in cell proliferation, differentiation, and cancer development. He has held the Canada Research Chair in Intracellular Signalling since 2004.
Education:
- PhD in Biochemistry from University of Montreal (1993)
- Postdoctoral training at UC Berkeley with Gerald M. Rubin (1993–1999)
Research Interests:
His lab uses Drosophila genetics and molecular biology to study signaling proteins in the RAS pathway, including KSR and CNK. Key projects involve identifying therapeutic targets for cancers linked to RAS pathway mutations. Recent work includes elucidating mechanisms of RAF kinase activation and developing inhibitors targeting RAS-MAPK signaling.
Grants & Awards:
- Multiple grants from the Canadian Institutes of Health Research (CIHR), FRQS, and others
- Canada Research Chair renewals (2004, 2009, 2017)
- 2011 Quebec Science Top 10 Discovery for work on the EJC complex
Advising & Labs:
- Supervised over 10 PhD and Master’s students
- Leads the IRIC’s signal transduction research unit
- Collaborates with teams on drug discovery for cancer
Labs & Teams:
His lab is part of the IRIC, a center focused on translational cancer research. Current projects include developing inhibitors for RAS-driven cancers and investigating CNK2’s role in metastasis.
