معرفی
Dr. Marc-David Ruepp is a Reader in RNA Biology and Molecular Neurodegeneration at King’s College London, where he leads the RueppLab. He is also a Fellow of the United Kingdom Dementia Research Institute and an Academic Mentor for PhD students in the Department of Basic & Clinical Neuroscience. His research focuses on RNA metabolism dysfunction in neurodegenerative diseases like ALS and frontotemporal dementia, emphasizing the molecular mechanisms underlying selective neuronal death.
His research interests span RNA biology, neurodegeneration, and gene expression regulation, with a particular emphasis on FUS protein interactions and mitochondrial dysfunction in ALS.
Key publications highlight advancements in understanding ALS pathogenesis via RNA-based approaches and CRISPR technologies, along with studies on mitochondrial defects in motor neurons and phase-separated RNA structures in disease contexts. Collaborators include Prof. Chris Shaw and Dr. Caroline Vance at King’s College London, and Prof. Frederic Allain at ETH Zurich.
Ruepp has secured grants such as the MND Translational Accelerator awards and leads projects on RNA-based therapies for ALS and synaptic dysfunction mechanisms.
