معرفی
Dr. Jackie Mitchell is a Lecturer in In Vivo Modelling of Neurodegeneration at King's College London, affiliated with the Department of Basic & Clinical Neuroscience, School of Neuroscience, and the Institute of Psychiatry, Psychology & Neuroscience. Her research focuses on neurodegenerative diseases such as Alzheimer's and ALS, emphasizing mitochondrial dysfunction and ER-mitochondria interactions. She employs in vivo models to study disease mechanisms and develop therapeutic strategies.
Key research themes include TDP-43 pathology, ER-mitochondria tethering proteins (VAPB-PTPIP51), and the role of mitochondrial homeostasis in neurodegenerative diseases. Her work bridges basic science and translational research, with contributions to understanding ALS/FTD and Alzheimer's disease mechanisms.
Her articles highlight advancements in ER-mitochondria signaling, mitochondrial dynamics, and the molecular links between diabetes and Alzheimer's. She has secured significant grants, including a £1.5M LifeArc partnership for MND treatment development and a £1.3M MRC grant on neuronal signaling studies.
Dr. Mitchell collaborates with institutions like King's College London and the University of York. Her lab explores therapeutic approaches using in vivo models, and she serves as a co-investigator on projects like the MNDSTaR initiative and studies on VAPB-PTPIP51 signaling.
