معرفی
Christopher Miller is a Professor of Molecular Neuroscience at King's College London, affiliated with the Department of Basic & Clinical Neuroscience within the Institute of Psychiatry, Psychology & Neuroscience. His work focuses on molecular mechanisms underlying neuronal cell death in neurodegenerative diseases like Alzheimer's, ALS, and Parkinson's. He leads the Chris Miller Lab, investigating ER-mitochondria signaling disruptions in these diseases and exploring therapeutic interventions.
Research Interests: His lab studies how defects in endoplasmic reticulum-mitochondria communication contribute to neurodegeneration. Key areas include calcium homeostasis, mitochondrial function, and autophagy. Techniques used include cell models, transgenic mice, zebrafish, and human iPS-derived neurons.
Grants & Collaborations: Recent funding includes a £1.3 million MRC grant (2023) for ER-mitochondria signaling studies. Collaborators include Dr. Wendy Noble and Prof. Christopher Shaw at King's College London. Active projects include VAPB-PTPIP51 protein studies and Sigma-1 receptor signaling investigations.
Publications: Over 100 peer-reviewed articles, with recent work on ER-mitochondria tethering proteins, ALS/FTD mutations, and therapeutic target identification. Key journals include Acta Neuropathologica Communications and Aging Cell.
