Malin Lindqvist Appell

Malin Lindqvist Appell is the Deputy Dean and Senior Associate Professor at Linköping University's Department of Biomedical and Clinical Sciences (BKV), affiliated with the Faculty of Medicine and Health Sciences (MEDFAK). Her research focuses on pharmacogenetics and thiopurine metabolism, particularly the role of genetic variants in the thiopurine methyltransferase (TPMT) enzyme. She co-leads the international TPMT Nomenclature Committee, standardizing genetic variant naming. Her work integrates cellular studies, protein stability analysis, and clinical applications to improve chemotherapy safety through personalized dosing. Key contributions include understanding genetic influences on drug metabolism and developing biomarkers for therapy optimization.

Research interests span pharmacogenetic individualization of chemotherapy, enzyme polymorphisms in drug response, and translational applications of genetic data. She collaborates with international teams on projects like the NOPHO ALL2008 leukemia study. Her lab uses cancer cell lines and recombinant protein studies to explore metabolic pathways and drug interactions. Recent work includes LC-MS/MS quantification of thiopurine metabolites and GST genotype impacts on autoimmune hepatitis treatments.

Advising and grants are central to her role, though specific student names or grant details are not listed. She contributes to the Division of Clinical Chemistry and Pharmacology (KKF), which spans anesthesiology, forensic sciences, and clinical chemistry research. Her long-term goals include advancing precision medicine through pharmacogenetic insights and improving patient safety in chemotherapy regimens.