معرفی
Professor Malcolm Irving FRS is a Professor in the Randall Centre for Cell & Molecular Biophysics at King's College London, within the School of Basic & Medical Biosciences. His research focuses on molecular mechanisms of muscle contraction and regulation in skeletal and cardiac muscle, particularly investigating thick filament regulation, myosin motor dynamics, and mechano-sensing mechanisms. He leads the Irving Group, part of King’s MechanoBiology Centre, which employs advanced techniques like X-ray diffraction and fluorescence microscopy to study protein structure-function relationships in intact muscle cells.
Key collaborations include work with the European Synchrotron Radiation Facility and the Advanced Photon Source. Irving has secured major grants from the Wellcome Trust, BHF British Heart Foundation, and MRC. His contributions include over 100 peer-reviewed articles, with recent work highlighting dual-filament regulation in skeletal muscle and the role of thick filament mechano-sensing in heart function.
Scientific accolades include Fellowship of the Royal Society (FRS). His research group actively recruits postdocs and technicians, with current students including Jess Chandler. Projects span structural biology, drug mechanism studies (e.g., levosimendan), and molecular basis of heart diseases like hypertrophic cardiomyopathy.
