معرفی
David M. Warshaw is a Professor and Chair of the Department of Molecular Physiology and Biophysics at the University of Vermont's Larner College of Medicine. He earned his Ph.D. in Physiology and Biophysics from UVM in 1978 and completed postdoctoral work at UMass Medical School on smooth muscle mechanics.
- Ph.D. (1978) - University of Vermont, Physiology & Biophysics
- Postdoctoral Training - University of Massachusetts Medical School, Single Smooth Muscle Cell Mechanics
The Warshaw Molecular Motors Group investigates two primary areas: (1) myosin and kinesin molecular motors and their regulation in intracellular cargo transport systems, and (2) cardiac and skeletal muscle contractility mechanisms related to heart failure. Their work employs single molecule biophysics, laser trapping, and super-resolution microscopy to analyze these processes at the molecular level.
Key research trends from his publications include: (1) ATP consumption dynamics in resting skeletal muscle using single molecule techniques (2020), (2) Ultrafast zebrafish swimming muscle mechanics (2020), (3) Myosin binding protein-C (MyBP-C) isoform effects on skeletal muscle contractility (2019), and (4) 3D actin network transport mechanisms by myosin Va (2019). These studies frequently intersect with genetic disease research, particularly regarding hypertrophic cardiomyopathy and developmental muscle disorders.
Scientific Distinctions:
- Established Investigator & Fellow - American Heart Association
- Fellow - Biophysical Society
As principal investigator on NIH Program Project Grants, Dr. Warshaw has trained 26 pre- and postdoctoral fellows, 17 of whom have transitioned to university faculty positions. His lab team includes researchers like Brandon Bensel, Andy Mead, and Guy Kennedy.
The group maintains affiliations with UVM's Cardiovascular Research Institute and employs comparative approaches across diverse myosin variants to understand physiological motion mechanisms from cardiac pumping to intracellular transport phenomena.
