معرفی
Makoto Sahara is an Adjunct Associate Professor in the Department of Surgery at Yale School of Medicine. He holds an MD from Osaka University (1998) and a PhD from Tokyo University (2007). His research focuses on cardiovascular development, stem cell biology, and regenerative medicine, particularly exploring molecular mechanisms underlying cardiomyogenesis and vasculogenesis during heart development. Dr. Sahara has pioneered studies using bioengineering strategies for cardiac repair and employs cutting-edge techniques like single-cell RNA sequencing to analyze cardiac cell populations.
Key research areas include: 1) Molecular regulation of vascular smooth muscle differentiation in embryonic heart development, 2) Role of paracrine mediators in cardiac regeneration, 3) Identification of essential genes (e.g., ZIC2, STRA6) controlling cardiac progenitor cell fate, and 4) Development of mRNA-based assays for studying proteasomal degradation pathways in cardiomyopathies. His work bridges basic science and translational medicine, with over 45 peer-reviewed publications and 1,447 citations.
Dr. Sahara collaborates extensively with institutions globally, contributing to advancements in heart regeneration research and stem cell applications. His lab focuses on translating discoveries in developmental cardiology into novel therapeutic strategies for cardiovascular diseases. Current projects emphasize bioengineered cardiac tissues and CRISPR-based functional genomics approaches.
