معرفی
Hongchao Guo is an Assistant Professor of Cardiothoracic Surgery and Adjunct Assistant Professor of Human Genetics at the University of Utah Health Sciences Center. He is affiliated with the Molecular Biology Program and Biological Chemistry Program, where his research focuses on cardiovascular development, stem cell differentiation, and precision medicine approaches for cardiovascular disease.
Education:
- Ph.D. from Nankai University
- Postdoctoral training at the Stanford Cardiovascular Institute
Research Focus:
Dr. Guo's laboratory employs human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) to investigate the genetic and epigenetic mechanisms underlying cardiovascular development and disease. His work integrates molecular biology, next-generation sequencing, and genome editing technologies to pioneer precision medicine strategies for cardiovascular disease (CVD) patients.
Key research areas include:
- Heart development and regeneration: Studying embryonic heart formation and enhancing cardiac regenerative potential using 2D and 3D stem cell models.
- Cardiovascular disease modeling: Creating patient-specific iPSC-derived cardiovascular cells to understand genetic and environmental contributions to CVD susceptibility.
- Novel molecular targets: Identifying factors like lncRNA BANCR and epigenetic regulator SETD7 critical for cardiac lineage specification.
Publications:
His recent work spans RNA editing in vascular smooth muscle (ADAR1 studies), epigenetic regulation of CVD, and CRISPR-edited iPSC models for variant pathogenicity assessment. Notable contributions include Science Translational Medicine (2023) on SGLT2 inhibitors and Cell (2015) on provirus silencing in embryonic stem cells.
Laboratory and Teams:
Dr. Guo leads a dynamic research group at the University of Utah, leveraging advanced stem cell technologies and genomic tools. His lab collaborates extensively with the Stanford Cardiovascular Institute and other interdisciplinary teams to translate findings into therapeutic strategies.
