معرفی
Maja Jagodic is a Professor of Neuroinflammation and Associate Professor in Experimental Medicine at Karolinska Institutet, leading the research group 'Epigenetic origins and mechanisms in neuroinflammation' within the Department of Clinical Neuroscience. Her work focuses on understanding how epigenetic mechanisms link genetic and environmental factors to neuroinflammatory diseases, particularly multiple sclerosis (MS). She holds a PhD from Karolinska Institutet (2004) and a Docent title (2014).
- Affiliations: Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska University Hospital.
- Key collaborations: International Multiple Sclerosis Genetics Consortium (IMSGC), International Human Epigenome Consortium (IHEC).
Research Interests: Epigenetic regulation in neuroinflammation, MS pathogenesis, biomarker discovery, and personalized treatments. Specific areas include DNA methylation, non-coding RNAs, and immune cell dysfunction in MS.
Publications highlight epigenetic mechanisms underlying MS progression, genetic-epigenetic interactions, and therapeutic targets like HB-EGF and autophagy pathways. Recent work explores smoking's epigenetic effects on MS patients and aging's role in neurodegeneration.
- Grants & Funding: Over SEK 1.8M from Swedish Brain Foundation (2022-2023), StratNeuro Funding for postdoctoral researchers, and Knut and Alice Wallenberg Foundation support.
Led research identifying T-bet+ B cells' role in MS pathogenesis and developed tools for multi-omic data integration (e.g., GeneSetCluster 2.0). Active in mentoring PhD students and postdocs, with a focus on translational epigenetics.
Lab Members: Includes 10+ researchers, including PhD students Yufei Cheng and Yanan Han, and team leaders like Lara Kular (lung-brain axis) and Milena Zeitelhofer Adzemovic (mental health).
