معرفی
Madeleine M. E. Hayman is a researcher affiliated with the School of Health and Wellbeing and School of Cardiovascular and Metabolic Health at the University of Glasgow, with additional affiliation at the University of Edinburgh's Deanery of Molecular, Genetic and Population Health Sciences. Supported by the MRC DTP Precision Medicine Programme, she conducts genetic research focusing on the intersection of mental health and cardiometabolic diseases.
Her research interests center on genetic associations between the GLP1R locus and both mental ill-health endophenotypes (including risk-taking behavior, mood instability, and chronic pain) and cardiometabolic traits. She employs trans-ancestry analysis within the UK Biobank dataset to examine how genetic variations in this receptor relate to conditions like type 2 diabetes, body mass index, and blood pressure across different population groups.
Her recent publication in Diabetes, Obesity and Metabolism demonstrates that GLP1R variants show consistent associations with cardiometabolic traits across all ancestry groups, but exhibit more variable effects on mental ill-health phenotypes. This suggests that behavioral changes associated with GLP-1 receptor agonists may not be directly mediated through the GLP1R pathway itself, providing important clinical insights for diabetes and obesity medications.
Hayman's work has been supported by major funding bodies including the Wellcome Trust, Medical Research Council, Department of Health, UK, Scottish Government, and British Heart Foundation through the UK Biobank project.
As a researcher in training through the MRC DTP Precision Medicine Programme, Hayman contributes to understanding the complex relationships between metabolic health and mental wellbeing, with implications for both clinical practice and pharmaceutical development.
