معرفی
Mélanie Hamon is a Structure Manager at the Pasteur Institute leading the Chromatin and Infection research team within the Cell Biology and Infection department. Her work focuses on epigenetic mechanisms in host-pathogen interactions, particularly studying Listeria monocytogenes and Streptococcus pneumoniae infection models.
- 2024 Chair of Excellence awardee
- 2024 publication on S. pneumoniae epigenetic memory
- 2024 discovery of host-directed oxadiazole compounds for tuberculosis
Her research explores how:
- Bacterial pathogens modify chromatin to manipulate host transcription
- Epigenetic immune memory develops after infections
- Host metabolic pathways support pathogen replication
- Membrane dynamics facilitate intracellular niche formation
- Post-translational histone modifications affect infection outcomes
Key methodologies include ChIP-seq, CRISPR, and mass spectrometry, with recent publications (2024) showing:
- Epithelial cell memory mechanisms
- Zinc poisoning in host-directed therapy
- SNX8-RAB11A axis in vacuole rupture
- Collagen induction via plasma activation
Scientific contributions include:
- Discovered SIRT2-TDP-43 interaction in 2021
- Identified IAM subpopulation dynamics in 2024
- Elucidated KDM6B's role in 2021
Current advisees:
- PhD student: Justine Matheau
- PhD student: Leonardo Gonzalez-Smith
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