معرفی
Dr. Lynn McKeown is an Associate Professor in Vascular Cell Biology at the University of Leeds, affiliated with the Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) within the School of Medicine. Her research focuses on molecular mechanisms regulating vascular function, particularly calcium signaling and Weibel-Palade body (WPB) trafficking in endothelial cells.
- Education:
- PhD in Integrin Dynamics (2000-2004), University of Manchester
- BSc (Hons) Biomedical Sciences (1996-2000), University of Manchester
McKeown's research explores how calcium signaling pathways interact with Rab GTPases (notably Rab46) to control WPB secretion, linking these processes to cardiovascular disease (CVD) and diabetic vascular complications. Her work aims to identify novel therapeutic targets for CVD treatment.
Recent publications highlight her discovery of Rab46's role in calcium-dependent WPB trafficking, its implications in diabetes-related vascular dysfunction, and cross-disciplinary connections to COVID-19 fatality and primary immunodeficiencies. She has secured significant funding from the British Heart Foundation (BHF), MRC, and Royal Society for her work.
- Scientific Awards:
- Faculty of 1000Prime Recommended (2019)
McKeown serves as a Principal Investigator and Lecturer in the School of Medicine, supervising PhD students and contributing to cardiovascular research training programs. Her affiliations include the Biochemical Society, Physiological Society, and European Calcium Society.
