معرفی
Lydie Pelinski is a University Professor at the University of Lille, affiliated with the Catalysis and Molecular Chemistry Department (CASECO). Her work bridges asymmetric homogeneous catalysis and organometallic biomolecule synthesis for therapeutic applications.
Research Highlights:
- Design of optically pure ferrocene diphosphines for asymmetric hydrogenation, achieving 64% enantioselectivity in acetophenone reduction
- Development of ferrocene-based antimalarials, including chloroquine derivatives in Phase II trials with Sanofi-Aventis
- Antitubercular studies focusing on ferrocene diamines, showing improved activity over traditional compounds
- Collaborative work on ferrocene antitoxoplasmosis agents with Lille University and Chiang Mai University
Scientific Trends:
The last 15 years of publications reveal consistent focus on ferrocene derivatives, copper complexes, topoisomerase inhibition, and green synthetic methods. Key methodologies include visible-light photocatalysis, multicomponent reactions, and organometallic drug design.Collaborations:
- Dr. Jeanne Maugein (Bordeaux) - Tuberculosis testing
- Dr. Sylvain Pellegrini - Joint catalysis/organometallic projects
- Madagascar partnerships for strychnobrasiline derivatives and ferroquine backup compounds
- INSERM U761 collaborations - Multicomponent syntheses
Education and Outreach:
She taught Organometallic Chemistry at ENSCL and Biocatalysis at Master's level. Active in the "Traveling Chemistry" program promoting post-baccalaureate chemistry education through hands-on experiments in regional schools.۰مقاله منتشرشده
