معرفی
Dr. Luigi Ombrato serves as Senior Lecturer and Group Leader of the Metastatic Niche Lab within the Centre for Tumour Microenvironment. His research program investigates cellular mechanisms driving metastasis formation, with emphasis on tumour microenvironment interactions and myeloid cell functions that enable disseminated cancer cell survival in distant organs.
His primary research domains include:
- Metastatic niche formation and colonization
- Neutrophil-macrophage cross-talk in metastatic progression
- Technical innovation for studying dormant cancer cells
- Therapeutic targeting of myeloid cell interactions
Recent publications (2019-2024) demonstrate methodological advances in metastasis research, particularly through novel cell-labeling techniques and analysis of radiation-induced immune responses. Key trends reveal growing focus on myeloid cell contributions to metastatic colonization and the development of tools for microenvironment interrogation.
Major recognitions include:
- CRUK Career Establishment Award (2024-2030; £744,160) for targeting myeloid cell cross-talk
- Academy of Medical Sciences Springboard Award (2022-2025; £99,997) for neutrophil-macrophage characterization
Dr. Ombrato leads active grant-funded projects developing therapeutic strategies against metastasis, with current work focusing on inhibiting myeloid cell interactions to prevent metastatic outgrowth. His lab maintains collaborations through memberships in the British Association for Cancer Research and European Association for Cancer Research.
The Metastatic Niche Lab employs advanced in vivo modeling and cell-labeling approaches to dissect microenvironmental drivers of metastasis, with ongoing projects analyzing parenchymal cell reprogramming and immune cell recruitment mechanisms.
