معرفی
Ludovic Deriano is a Principal Investigator and research leader at the Institut Pasteur in Paris, where he heads a team investigating DNA repair mechanisms in lymphocytes and their role in lymphoid cancers. His research bridges immunology, molecular biology, and oncology, focusing on how physiological DNA rearrangements contribute to genomic instability and tumorigenesis.
Research Interests: His work centers on DNA double-strand break repair, V(D)J recombination, class switch recombination, and chromosomal translocations. He explores how errors in these processes lead to cancers such as leukemia and lymphoma, with a particular focus on error-prone repair pathways like alternative NHEJ. His team also investigates therapeutic vulnerabilities in cancers like multiple myeloma.
Publication Trends: His recent publications (2020–2023) show a strong focus on DNA repair pathways (e.g., shieldin complex, SHLD1, MAD2L2), genomic instability in hematopoietic cancers, and therapeutic targeting in multiple myeloma. The research integrates molecular biology, genomics, and translational oncology, often published in top-tier journals like Nature, Cell Stem Cell, and Nature Communications.
Scientific Awards:
- Pasteur Vallery-Radot Prize 2023
Advising and Funding: Dr. Deriano mentors a diverse team including PhD students, postdoctoral fellows, and research engineers. He has led multiple funded projects, including an ERC Starting Grant (LymphoOncoGenomics) and several ongoing initiatives on DNA repair and cancer biology, indicating sustained research support.
Labs and Teams: He leads the DERIANO lab at the Institut Pasteur, which includes permanent researchers, postdocs, PhD students, and technical staff. The lab actively collaborates within the institute’s cancer and genomics initiatives, contributing to cross-functional projects such as the Drug Discovery & Screening platform and the Milieu Intérieur project.
