معرفی
Lin Zhang is a Professor of Medicine at the University of Southern California (USC), specializing in cancer biology with a focus on understanding mechanisms of drug resistance and cell death in colorectal cancer. His research intersects molecular oncology, pharmacology, and immunology, aiming to develop novel therapeutic strategies. Key projects include analyzing how anticancer drugs trigger programmed cell death pathways and identifying vulnerabilities in cancer cells.
Research interests center on proteins such as PUMA, Bax, and Mcl-1, which regulate apoptosis and necroptosis. His lab explores synthetic lethality in cancer therapies, the role of cancer stem cells in prevention, and the development of immunogenic cell death-inducing agents. Notable contributions include studies on KRAS-driven resistance mechanisms and the synergy between CDK inhibitors and immunotherapies.
Awards include the Hillman Fellow for Innovative Cancer Research (2010) and multiple grants from the American Cancer Society and V Foundation. His publications span over 200 peer-reviewed articles, with recent work emphasizing necroptosis modulation and targeted therapies for mismatch repair-deficient cancers.
Dr. Zhang’s lab actively investigates intestinal stem cell protection in radiation injury and leverages super-resolution imaging to study chromatin dynamics in early carcinogenesis. Collaborations bridge basic science and clinical translation, aiming to advance precision oncology.
