معرفی
Dongshi Chen, PhD, serves as an Assistant Professor of Research Medicine at the University of Southern California (USC), where his laboratory investigates molecular mechanisms of cell death pathways and their implications in chronic lung diseases and cancer. His work bridges basic science with translational applications for therapeutic development.
Dr. Chen's research program centers on:
- Cell Death Signaling (Necroptosis, Apoptosis)
- Lung Inflammation and Cigarette Smoke-Induced Injury
- COPD Pathogenesis and Progression
- Lung Cancer Development Mechanisms
- Cancer Therapy Resistance Pathways
- Aging-Related Disease Progression
His team examines the interplay between cell death mechanisms and inflammatory responses, with particular focus on elastase-mediated tissue damage (ELANE, MMP12) and immune cell activation (macrophages, neutrophils, T cells) in disease microenvironments. Current projects explore how aging modulates COPD progression and tumorigenesis at molecular levels.
Analysis of his 15 most recent publications (2021-2025) reveals consistent emphasis on necroptosis in COPD pathogenesis and multiple cancer types, especially colorectal cancer. His work demonstrates how defects in necroptosis contribute to therapy resistance across malignancies, and how targeting RIP3/PUMA pathways can restore treatment sensitivity - including novel applications for cancer immunotherapy. This body of work establishes cell death modulation as a promising strategy for overcoming treatment resistance.
