معرفی
Buse Cevatemre is a Research Fellow at Koç University specializing in anticancer drug development and epigenetic therapies. Her work focuses on overcoming chemoresistance in triple-negative breast and lung cancers through epigenetic targets like BRPF1 and LSD1. Research employs chemical biology approaches including chromatin-focused screens, metal complex synthesis, and combination therapy strategies.
Key research areas include: mechanism-based anticancer drug design, apoptosis induction pathways, cancer stem cell targeting, and metabolic regulation of drug resistance. Recent studies investigate ribosomal pathway modulation in taxane resistance and dual epigenetic inhibition strategies.
Publications (2018-2025) demonstrate expertise in metallodrug chemistry (Pt, Cu, V complexes), epigenetic vulnerability identification, and resistance mechanism elucidation. Methodologies span complex synthesis, epigenetic screening, apoptosis assays, and molecular pathway analysis across various cancer models.
