Lars Keld Nielsen

Lars Keld Nielsen serves as Scientific Director at the Novo Nordisk Foundation Center for Biosustainability within the College of Engineering at the Technical University of Denmark (DTU). His research integrates quantitative modeling with experimental biology to advance sustainable biomanufacturing solutions.

His primary research interests span Metabolic Modeling, Systems Biology, and Bioreactor Engineering, with significant contributions to mammalian cell engineering and microbial biotechnology. Current work focuses on genome editing for metabolic optimization, computational modeling of bioreactor dynamics, and high-throughput metabolomics workflows.

Analysis of his recent publications reveals strong emphasis on industrial biotechnology applications, particularly in:

• Metabolic engineering of mammalian cells for therapeutic protein production
• One-carbon feedstock utilization in bacterial systems
• AI-driven bioreactor process optimization

Nielsen actively supervises multiple PhD candidates including Muyo Abad, Chen T., and Volkova D. across projects focused on fermentation automation, human glycolysis modeling, and viral vector production. His research directly contributes to UN Sustainable Development Goals through sustainable biomanufacturing innovations.

Current projects include:

• PhD scholarship in Automation and Integration of Quantitative Fermentation Data (2025-2027)
• Computational kinetic modelling of human glycolysis (2024-2027)
• Mammalian cell engineering for rAAV production (2024-2026)