معرفی
Lalitha Madhavan is an Associate Professor in the Department of Neurology at the University of Arizona, where she leads research on neurodegenerative mechanisms and therapeutic development for Parkinson's disease using cellular and animal models.
Her research spans stem cell biology, oxidative stress pathways (particularly NRF2), neuroinflammation, and biomarker discovery. She employs patient-derived induced pluripotent stem cells (iPSCs), dermal fibroblasts, and transgenic mouse models to investigate protein misfolding, mitochondrial dysfunction, and cellular vulnerability in Parkinson's disease.
Analysis of her recent publications (2021-2025) reveals three dominant research thrusts: (1) NRF2 pathway modulation as a neuroprotective strategy against alpha-synuclein toxicity and ferroptosis, (2) development of brain-penetrant glycopeptide therapeutics for Parkinsonism and traumatic brain injury, and (3) establishment of dermal fibroblast-based biomarker platforms for Parkinson's disease diagnosis and monitoring. Her work demonstrates strong translational focus with emphasis on cognitive outcomes and sex-specific vulnerabilities.
Scientific Awards:
- No awards mentioned in source material
While specific advising relationships and grant details are not documented in the provided text, her publication record indicates active mentorship in neuroscience and translational research. Her laboratory likely engages in collaborative projects spanning molecular neuroscience, pharmacology, and neurodegenerative disease modeling.
Research infrastructure appears centered on cellular and animal model systems for Parkinson's disease, with particular expertise in iPSC-derived dopamine neurons, neuroinflammatory profiling, and behavioral phenotyping in progressive disease models.
