Wim Mandemakers

Wim Mandemakers is an Assistant Professor in the Department of Clinical Genetics at Erasmus MC, focusing on neurogenetic disorders and molecular mechanisms underlying Parkinson's disease. His research integrates genetic analysis, molecular biology, and cellular models to uncover disease pathways. Collaborations include the International Parkinsonism Genetics Network and Mediterranean Parkinson disease Genetics Study Group.

Key research interests include α-synuclein pathology, LRRK2 kinase dysfunction, and metabolic dysregulation in Parkinson's. He develops innovative tools like the deCLUTTER pipeline for stem cell-based astrocyte analysis. His work bridges clinical genetics with experimental models to address neurodegenerative mechanisms.

Recent studies highlight glycative stress in early-onset Parkinsonism and PTPA/PP2A dysfunction links to intellectual disability. Findings are published in journals like Molecular Metabolism, Brain, and Disease Models & Mechanisms.