معرفی
Kyle Biggar is an Associate Professor at the Department of Biology, Faculty of Science, Carleton University. His research bridges functional proteomics, post-translational modifications (particularly lysine methylation), and their roles in cancer and hypoxia. He leads a multidisciplinary lab with expertise in biochemical techniques, peptide array synthesis, and computational modeling of enzyme-substrate interactions.
- Education: B.Sc. (St. Francis Xavier), Ph.D. (Carleton)
- Research Themes: Regulation of protein interaction networks by lysine methylation, hypoxia signaling, therapeutic peptide design, and environmental stress adaptation
- Collaborations: Co-supervises students with Dr. James Green, partners with NuvoBio for cancer therapeutics
His publications focus on enzyme specificity, methyllysine proteomics, and stress-responsive microRNA mechanisms. The lab trains students in advanced cellular and biochemical methods, with alumni contributing to fields like neurodegenerative disease and DNA repair.
Recent work includes AI-driven protein interaction prediction, exploring lysine PTM competition in cancer, and developing KDM5C/SETD6 inhibitors. The lab also investigates mTOR-IGFBP-1 signaling in intrauterine growth restriction and employs peptide arrays for drug discovery.
Lab Members & Students:
- Current: Francois Charih (NSERC PGS-D), Ruofan Wang, Mullen Boutler, Mitch Allen, Ella De Nicola, Johanna Enright
- Alumni: Dr. Hemanta Adhikary (KMT/KDM inhibitors), Viktoria Xing (methyl-binding domains), Ryan Collins (MLL4 substrates)
