Karel Bezstarosti

Karel Bezstarosti is an active Researcher in the Department of Biochemistry at Erasmus MC, Faculty of Medicine. His research spans multiple areas of molecular and cellular biochemistry with particular expertise in proteomics, ubiquitin signaling pathways, and DNA repair mechanisms. He maintains active collaborations within Erasmus MC and with international research teams.

Bezstarosti's research interests focus on proteomics, ubiquitin signaling, transcription regulation, and mass spectrometry applications. His work particularly examines protein modification systems, DNA repair mechanisms including nucleotide excision repair and base excision repair, and the dynamics of molecular interactions in cellular processes. His fingerprint analysis shows strong concentrations in proteomics (100%), ubiquitin pathways (70%), transcription regulation (66%), and mass spectrometry (63%).

Recent publications demonstrate Bezstarosti's focus on deubiquitinating enzymes, neuronal differentiation mechanisms, immunopeptidome analysis for vaccine development, and transcription-coupled DNA repair. His work bridges basic biochemical mechanisms with potential clinical applications, particularly in neurodevelopmental disorders and cancer immunotherapy. The consistent publication record in high-impact journals like Nature Chemical Biology, Genes and Development, and Molecular Cell indicates sustained research productivity.

Bezstarosti maintains active research collaborations across multiple institutions, with recent external collaborations spanning various countries as indicated by the network visualization in his profile. His work shows interdisciplinary connections between biochemistry, molecular biology, neuroscience, and immunology.