معرفی
Kaixiang Cao is an Assistant Professor in the Department of Biochemistry and Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine. He is also a member of the Cancer Genomics and Epigenomics Program at the Case Comprehensive Cancer Center.
Research Interests: Dr. Cao's lab investigates epigenetic mechanisms—including histone modifications, DNA methylation, and nucleosome positioning—in relation to stem cell fate determination, enhancer function, and disease pathogenesis. His work focuses on lysine methyltransferases/demethylases (KMTs/KDMs), COMPASS family proteins, and chromatin architecture in developmental and cancer contexts.
Publication Trends: Recent studies (2020-2025) emphasize synergistic epigenetic pathways (e.g., H3K79/H3K36 methylation), enhancer regulation, and non-canonical roles of chromatin modifiers like LSD1 and DOT1L. Earlier work (2012-2014) established foundational insights into linker histone variants, Hox gene regulation, and transcriptional control in stem cells.
Mentoring & Collaboration: The lab is dedicated to training biomedical scientists and translating epigenetic discoveries into therapeutic strategies for developmental syndromes and cancer.
