معرفی
Erin Green is an Associate Professor in the Department of Biological Sciences at the University of Maryland, Baltimore County (UMBC), where she leads an active research laboratory investigating epigenetic regulation through protein post-translational modifications. Her work integrates molecular biology, genetics, biochemistry, genomics, and proteomics using Saccharomyces cerevisiae and mammalian models to study chromatin signaling pathways in gene expression and stress response.
Education:
- Postdoctoral Fellowship, Stanford University (2013)
- Ph.D., University of California, Berkeley (2007)
- B.A., Bryn Mawr College (2000)
Dr. Green's research focuses on how histone methylation, particularly at lysine residues, regulates chromatin structure and function to maintain genomic integrity during cellular stress and gene expression. Her lab investigates canonical and novel methylation sites, non-histone protein methylation, and the role of lysine methyltransferases like Set5 and SMYD proteins in telomere maintenance and cancer pathways. Using evolutionary conserved yeast models, her work provides insights into human diseases including tumorigenesis and aging-related pathologies.
Analysis of her 15 most recent publications reveals consistent emphasis on chromatin stress responses, telomere biology, and lysine methylation signaling. Key trends include: (1) mechanistic studies of SET domain proteins in stress adaptation, (2) crosstalk between histone modifications and DNA repair, (3) translational implications for cancer metastasis (particularly prostate cancer via SMYD3-MAP3K2 axis), and (4) development of yeast models for human aging processes. Her work bridges fundamental chromatin biology with disease mechanisms through conserved epigenetic pathways.
Dr. Green has secured significant research funding including multiple NIH grants: a funded R01 on lysine methylation in chromatin and stress responses (2017-2022), an active project on SMYD lysine methyltransferase Set6 (2023-present), and previously funded work on telomere chromatin homeostasis (2016). She actively mentors graduate students including recent PhD graduates (Maraki Negesse, Elgar Gabibov) and current candidates (Chase Andre, Fidelia Asomani), with several trainees presenting at national conferences and publishing high-impact work.
The Green Lab maintains a dynamic research environment within UMBC's Biological Sciences Building, characterized by frequent conference presentations (ASBMB, FASEB), collaborative projects, and integration of undergraduate researchers through programs like Meyerhoff and U-RISE. Current work focuses on lysine methylation signaling in stress responses, with ongoing projects examining noncanonical SET domain functions and SMYD methyltransferase roles in proteostasis.
