معرفی
Junichi Saito, PhD, MD, is a Research Fellow at Yale School of Medicine’s Department of Internal Medicine, affiliated with the Greif Lab. He holds dual doctorates from Yokohama City University (PhD, 2019) and Gunma University (MD, 2007). His research focuses on vascular biology, particularly in arterial development, congenital heart defects, and tissue-engineered vascular grafts. Saito has pioneered studies on molecular mechanisms underlying ductus arteriosus closure, elastin-deficient aortopathy, and pathological muscularization in pulmonary hypertension. He is also a leader in bioreactor-engineered vascular grafts using human cells.
Notable achievements include the NIH Pathway to Independence Award (2024), 1st place in the American Physiological Society’s Cardiovascular Section (2025), and multiple early-career accolades from the American Heart Association and Japanese Societies. His work bridges molecular pathology with translational regenerative medicine, addressing critical needs in pediatric and adult cardiovascular care.
Research highlights include elucidating TGFβ/ANGPT2 signaling in germinal matrix hemorrhage, NOTCH3-driven aortic stenosis mechanisms, and scaffold-free arterial bioengineering. Saito collaborates widely with teams at Yale and globally, contributing to over 20 peer-reviewed publications since 2016. His lab focuses on translational solutions for congenital vascular anomalies and engineered blood vessel replacements.
