معرفی
Daniel Greif is Professor of Medicine (Cardiovascular Medicine) and Professor of Genetics at Yale School of Medicine. He serves as Co-Director of the Yale Cardiovascular Research Center (YCVRC) and leads an active research laboratory focused on vascular and pulmonary pathobiology.
Education:
- BS, Stanford University (1991)
- MD, University of California-San Francisco (1997)
- Intern & Junior Resident, University of Washington (1999)
- Senior Resident, Brigham & Women's Hospital (2000)
- HHMI Postdoctoral Fellow, Brigham & Women's Hospital (2003)
- Clinical Fellow, Stanford University (2007)
- Post-doctoral Fellow, Stanford University (2010)
Daniel Greif’s research centers on the development and disease of blood vessels and the lung, particularly focusing on vascular mural cells (smooth muscle cells and pericytes) and fibroblasts. His lab investigates how these cells contribute to pathologies such as pulmonary hypertension, atherosclerosis, and lung fibrosis. He employs multidisciplinary approaches including genetics, epigenetics, developmental biology, and computational methods to uncover mechanisms of vascular morphogenesis, maintenance, and disease.
The recent publications highlight a strong trend in vascular and fibrotic disease mechanisms. Key themes include the role of smooth muscle progenitors in vascular pathologies, epigenetic regulation of fibroblasts in lung fibrosis, signaling pathways (e.g., LXR, TGFβ, HIFα) in vascular remodeling, and the crosstalk between endothelial and mural cells. His work bridges basic science with clinical relevance, often validating findings in animal models and human samples.
Daniel Greif is deeply committed to mentoring young trainees and translating fundamental discoveries into novel therapeutics. He is actively involved in collaborative research across Yale, including affiliations with the Vascular Biology and Therapeutics Program, Yale Stem Cell Center, and the Yale Combined Program in the Biological and Biomedical Sciences (BBS). His lab continues to explore arterial development, aging, and disease mechanisms with a focus on progenitor cell biology and epigenetics.
