معرفی
Kathleen Martin is a Professor of Medicine (Cardiovascular Medicine) and Pharmacology at Yale School of Medicine, where she also serves as Co-Director of the Yale Cardiovascular Research Center (YCVRC). Her academic journey began at Hiram College where she earned her BA in Biology (1990), followed by a PhD in Physiology and Biophysics from Case Western Reserve University (1997), and postdoctoral training at Harvard Medical School (1998-2000).
- BA in Biology, Hiram College (1990)
- PhD in Physiology and Biophysics, Case Western Reserve University (1997)
- Postdoctoral Fellowship, Harvard Medical School (1998-2000)
Dr. Martin's research focuses on the molecular mechanisms regulating vascular smooth muscle cell (SMC) phenotypic plasticity, with particular emphasis on epigenetic regulation through enzymes like TET2. Her work explores how SMCs maintain the ability to de-differentiate and re-enter the cell cycle, which is essential for angiogenesis but also contributes to atherosclerosis, intimal hyperplasia, and restenosis. She investigates the mTOR pathway's role in SMC differentiation and how rapamycin affects vascular disease processes, aiming to develop novel therapeutics that avoid the adverse effects of systemic rapamycin treatment.
Analysis of Dr. Martin's most recent publications reveals a strong focus on vascular remodeling mechanisms, with particular attention to epigenetic regulation of SMC phenotype, TET2-mediated chromatin remodeling, and the intersection of vascular biology with immunology and developmental processes. Her work spans from basic molecular mechanisms to translational applications in vascular disease treatment.
- Alexander W. Clowes Distinguished Lecturer (2022)
Dr. Martin has held significant leadership roles including Chair of the AHA Vascular Discovery Meeting Planning Committee and service on the Yale IACUC. She collaborates extensively with researchers across Yale and beyond, particularly with John Hwa, Alan Dardik, and Daniel Greif. Her lab participates in multiple institutional programs including the Vascular Biology and Therapeutics Program, Yale Combined Program in the Biological and Biomedical Sciences, and the Yale Stem Cell Center.
The Martin Lab, located within the Department of Cardiovascular Medicine, focuses on understanding how regulation of the muscular layer of blood vessels contributes to normal vessel function and cardiovascular disease. The lab investigates key areas including vascular smooth muscle differentiation, signal transduction, transcription, and epigenetics using disease models of atherosclerosis, intimal hyperplasia, transplant vasculopathy, obesity, and diabetes.
