Jose Alfonso Rodriguez

José Alfonso Rodriguez is an Associate Professor in the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA), affiliated with the College of Letters and Science. He holds a PhD in Molecular Biology from UCLA (2012) and leads research initiatives in structural biology and biophysical chemistry.

• Research Focus: MicroED (Micro Electron Diffraction), cryo-EM, protein aggregation, prion diseases, amyloid structures, and small-molecule crystallography.
• Funding: NIH R35GM128867 (2018-2023) for studying toxic macromolecular nanoassemblies; NIH R21AI135851 (2018-2021) for developing hemorrhagic fever therapeutics.

Recent publications highlight his work in MicroED methodology for nanocrystallography, structural analysis of amyloid fibrils, and innovative approaches in enzyme-inhibitor complex determination. Collaborations span UCLA's Eisenberg and Gonen labs, with cross-disciplinary applications in biophysics and drug discovery.