David S Eisenberg

David S. Eisenberg is a Professor of Biological Chemistry at the David Geffen School of Medicine, UCLA. His research focuses on understanding the structural basis of protein aggregation and amyloid diseases, with a particular emphasis on Alzheimer's, Parkinson's, and other neurodegenerative disorders. He leads interdisciplinary projects funded by NIH grants, including studies on tau protein polymorphs, amyloid-beta structures, and the development of inhibitors for amyloid diseases.

Eisenberg's work combines structural biology techniques (e.g., cryo-electron microscopy, micro-electron diffraction) with biochemical and computational methods. His team has published extensively on amyloid fibril structures, peptide-based therapeutics, and the mechanisms of protein misfolding. Notable contributions include identifying novel amyloidogenic proteins, designing structure-based inhibitors, and elucidating the role of low-complexity domains in aggregation.

He has collaborated on projects such as the Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs and pioneered methods like IMPAcT for identifying disease-related proteins. His research bridges basic science and translational medicine, aiming to develop diagnostics and treatments for amyloid-related diseases.