Jonathan Weissman

Jonathan Weissman is a Professor in the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco (UCSF), where he leads a highly influential research group at the forefront of systems biology, genomics, and genetic engineering. His work spans molecular pharmacology, synthetic biology, and cellular systems, with a focus on developing and applying cutting-edge technologies such as CRISPR, ribosome profiling, and Perturb-seq to interrogate gene function and regulation at scale.

His research interests are centered on understanding the principles of gene expression, protein homeostasis, and cellular responses to stress. He has pioneered methods for genome-wide functional screening, translational regulation analysis, and single-cell genomics. His lab has developed tools for CRISPR interference (CRISPRi), ribosome profiling, and high-content genetic interaction mapping, which have been widely adopted in the scientific community. These approaches enable systematic dissection of complex biological processes, including protein folding, mitochondrial function, and immune cell regulation.

The recent publications reflect a strong emphasis on single-cell resolution studies, in vivo screening, and the functional annotation of non-canonical genomic elements. Themes include CRISPR-based perturbation screens, spatial and temporal modeling of molecular systems, immune checkpoint regulation in cancer, and the role of non-coding RNAs in cell fate decisions. His work increasingly integrates multi-omics approaches to map regulatory networks with high precision.

Dr. Weissman has mentored numerous students and postdoctoral researchers, many of whom have become independent investigators. His group collaborates extensively across disciplines and institutions, contributing to large-scale initiatives such as the Human Cell Atlas. He has not received any explicitly named scientific awards in the provided text, but his publication record in top-tier journals underscores his scientific impact.

He leads a dynamic research laboratory focused on developing and applying scalable technologies for functional genomics. The lab emphasizes innovation in experimental design, computational analysis, and the translation of basic discoveries into biomedical applications, particularly in cancer and neurodegenerative diseases.