Sherman Weissman

Sherman Weissman is the Sterling Professor of Genetics at Yale School of Medicine, with a primary appointment in the Department of Genetics. He is affiliated with several major research programs including the Genomics, Genetics, and Epigenetics Program, the Yale Cancer Center, the Yale Stem Cell Center, and Yale Ventures, reflecting his broad impact in biomedical research.

His research focuses on genomics, gene regulation, and molecular mechanisms in hematopoietic and immune cells. Key areas include genomic-scale analyses of transcription factor binding, chromatin structure, mRNA and protein expression patterns in immune cells, genome-wide mutation detection, and the role of the WRN helicase in DNA repair and aging. His work has significant implications for understanding cancer, immune function, and genetic disorders like Werner syndrome.

His recent publications, including a 2024 study on cnnImpute for single-cell RNA-seq data, demonstrate continued engagement in cutting-edge genomic technologies. Earlier work spans HLA gene characterization, globin gene expression, and cDNA cloning methods, showcasing a long-standing contribution to molecular genetics.

Sherman Weissman received his MD from Harvard University in 1955 and completed clinical training at Boston City Hospital and the National Cancer Institute. His career exemplifies a deep integration of clinical medicine and fundamental genetic research.

He has collaborated extensively with researchers such as Anna Szekely and has contributed to major advancements in genomic methodologies. His laboratory work has explored the functional roles of genes in the major histocompatibility complex and regulatory mechanisms in globin gene switching.